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Fig. 3 | Molecular Brain

Fig. 3

From: Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells

Fig. 3

Fer-1 ameliorates lipid peroxidation and neuronal damage in ECM mice. a Levels of MDA in the whole brain of control, ECM, and ECM mice treated with Fer-1 were measured with an MDA assay kit. Relative levels are shown as fold-changes in relation to control levels. Each point represents one animal. b Expression of NeuN (green) in the cerebrum of control, ECM, and Fer-1-treated ECM mice was detected by immunofluorescence staining and quantified based on fluorescent density. The nucleus was stained with DAPI (blue). Relative fluorescent density is shown as fold-change in relation to levels in control mice. Data are reported as the mean ± standard deviation. Each point represents one region of the immunofluorescence staining image. **p < 0.01 and ***p < 0.001 vs. control or ECM. ECM experimental cerebral malaria, Fer-1 ferrostatin-1, MDA malondialdehyde, NeuN neuronal nuclei

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