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Fig. 4 | Molecular Brain

Fig. 4

From: Increased spine PIP3 is sequestered from dendritic shafts

Fig. 4

The change in PIP3 levels in dendritic spines and shafts during neurodevelopment. A Representative images for each time point during neuronal development. The fluorescence lifetime values of dendritic shafts corresponding to dendritic spines were analyzed from the regions indicated by white rectangles in the image for 8 days. FLIMPA3 was transfected one day before observation in every experiment. White bar = 1 µm. B The change in the difference of fluorescence lifetime between dendritic spines and shafts during neuronal development. A total of 110 dendritic spines from 17 neurons were examined. The fluorescence lifetime of the dendritic spines from one neuron was averaged. The values were obtained by subtracting the fluorescence lifetime values of dendritic spines from the fluorescence lifetime values of the corresponding dendritic shafts. A correlation coefficient was calculated by least squares method. C The correlation between days in vitro and spine size. The number of spines same with B was analyzed

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