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Fig. 1 | Molecular Brain

Fig. 1

From: High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression

Fig. 1

HGP induce neurons to exhibit senescence-like phenotypes a Increase of SA-β-gal activity in PC12 cells induced by HGP. Scale bar, 50 μm. b Immunofluorescence staining of p16 in PCNs at control and HGP. Scale bar, 25 μm. c The expression of senescence marker proteins p16, p21 and γH2A.X in PC12 cells at control and HGP. d The expression of senescence marker proteins p16, p21 and γH2A.X in PCNs at control and HGP. Data are mean ± SD. n = 3 independent experiments for (a), (c) and (d), n = 4 independent experiments for (b). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Unpaired t test for (a), (c) and (d)

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