Fig. 1
From: Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
Intraperitoneal injection of donepezil downregulates Aβ pathology but not tau pathology in 5xFAD mice. 5xFAD mice were injected with vehicle (veh) or donepezil (1 mg/kg, i.p.) daily for 2 weeks, and immunofluorescence staining was conducted. A–G Representative images of immunohistochemical staining with Aβ pathology-related antibodies (veh, n = 4; DPZ, n = 5/group). H–P Representative images of immunohistochemical staining with tau pathology-related antibodies (veh, n = 4; DPZ, n = 5/group). Q–R Representative images of immunohistochemical staining with tau kinase p-Cdk5 antibody (veh, n = 4; DPZ, n = 5). Scale bar = 100 or 200 μm. *p < 0.05; **p < 0.01; ***p < 0.001