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Fig. 2 | Molecular Brain

Fig. 2

From: Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats

Fig. 2

Effects of retigabine on non-inactivating outward currents at NRs. A Two sets of sample traces show currents recorded at a NR following voltage steps in the absence (left, control) and presence of 10 µM retigabine (right). Circles and triangles indicate the beginning part and the end part of the outward currents, respectively. Currents at these two parts are used to plot I–V relationship in (B) and (C). B Left panel, I–V curve of the beginning part of the outward currents in the control (n = 6, open circle) and the presence of retigabine (n = 6, blue circle). Right panel, area under the I–V curve (AUC) of the beginning part of the outward currents in the control (n = 6, open bar) and the presence of retigabine (n = 6, blue bar). C Left panel, I–V curve of the end part of the outward currents in the control (n = 6, open triangle) and the presence of retigabine (n = 6, blue triangle). Right panel, AUC of the end part of the outward currents in the control (n = 6, open bar) and the presence of retigabine (n = 6, blue bar). AUC was used for statistical comparison of non-inactivating outward currents in the control and the presence of retigabine. Data represent mean ± SEM, ns, not significantly different, **p < 0.01, paired Student’s t-Test

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