Fig. 6

Effects of linopirdine and retigabine on saltatory conduction velocity. A Experimental setting for recording of AP propagation through NRs of lumbar spinal ventral nerves. APs were evoked from the distal site of the nerve bundle. B Two overlay sample traces show APs recorded from a NR following electrical stimulation. The recordings were performed in the absence (control, black) and presence of 100 µM linopirdine (red). C Two overlay sample traces show APs recorded from a NR following electrical stimulation. The recordings were performed in the absence (control, black) and presence of 10 µM retigabine (blue). In both (B) and (C), arrow indicates stimulation artifact. D Summary data of AP conduction velocity determined from the recordings exemplified in (B) in the control (n = 9) and the presence of linopirdine (n = 9). E Summary data of AP conduction velocity determined from the recordings exemplified in (C) in the control (n = 6) and the presence of retigabine (n = 6). Data represent mean ± SEM, ns, not significantly different, **p < 0.01, paired Student’s t-Test