Fig. 7

Effects of linopirdine and retigabine on high-frequency saltatory conduction. A Two sets of sample trances show APs recorded at a NR following a train of electrical stimulation at 500 Hz in control (top panel) and the presence of 100 µM linopirdine (bottom panel). Stimulation was applied for a period of 20 s. Only a short period of APs at initial time point (0 s), 5 s, 10 s, 15 s and 20 s time point are presented to illustrate changes of AP success rates over the time period of 20 s. B AP success rate at NRs with distal stimulation at frequency of 1, 10, 100, 200, 500 and 1000 Hz in the absence (n = 6) and presence of linopirdine (n = 6). Recording duration at each frequency was 20 s. C Comparison between averaged AP success rates at NRs at 500 Hz stimulation (n = 6). D Time course of AP success rate at NRs during a train of 500 Hz stimulation for 20 s. Black circles, control (n = 6); red circles, in the presence of linopirdine (n = 6). Time bin, 0.2 s. E Area under the curve of D for the control (open bar, n = 6) and the presence of linopirdine (red bar, n = 6). F Similar to (B) except retigabine was tested (n = 5). G Similar to C except retigabine was tested (n = 5). Data represent mean ± SEM, ns, not significantly different, ***p < 0.001, paired Student’s t-Test