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Fig. 2 | Molecular Brain

Fig. 2

From: A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

Fig. 2

The top 5 correlations between protein and anxiety, depression and neuroticism in male and female. Dots indicate protein specific betas; Horizontal lines represent 95% CI. * indicates the protein that has reached the significant threshold of Bonferroni correction (7.14 × 10− 4 for brain, 3.29 × 10− 4 for plasma, and 2.30 × 10− 4 for CSF). self, self-reported; r, Pearson correlation coefficient. Anxiety score, depression score, and neuroticism score were continuous phenotypic values of the residuals from linear regression models, while anxiety self and depression self were continuous phenotypic values of the residuals from logistic regression models. Anxiety score was defined according to the 7-item general anxiety disorder scale (GAD-7). Depression score was defined according to the Patient Health Questionnaire (PHQ-9). Neuroticism score was measured using the Eysenck Personality Questionnaire, and Revised Short Form (FPQ-R-S). The detailed description of neuroticism, anxiety and depression are shown in Additional file 1.

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