A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

Table 2 Association signals of common psychiatric disorder-related proteins in other proteomic studies

Protein	UniProt	Species	P _anxiety	P _depression	P _neuroticism	Design
CNTN2	Q02246	Rat	0.087	0.019	/	Proteomes by combining mass spectrometry [66]
MSP	P26927	Rat	4.82 × 10^− 7	1.23 × 10^− 6	/	Proteomes by combining mass spectrometry [66]
UBP25	Q9UHP3	Human	/	/	0.540	Proteomic [67]
PCSK9	Q8NBP7	Human	/	/	0.431	Proteomic [67]
C1–Esterase Inhibitor	P05155	Human	0.021	0.021	/	Proteomic [68]
C1–Esterase Inhibitor	P05155	Human	/	< 0.05	/	CSF proteome analysis [69]
ERBB1	P00533	Human	/	6.52 × 10^− 6	/	Combining GWAS and pQTL data [70]

CNTN2 contactin-2, MSP hepatocyte growth factor-like protein, UBP25 ubiquitin carboxyl-terminal hydrolase 25, PCSK9 proprotein convertase subtilisin/kexin type 9, C1-Esterase Inhibitor plasma protease C1 inhibitor, ERBB1 Epidermal growth factor receptor, CSF cerebrospinal fluid

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