Table 2 Gives an overview of the multi-subunit structure of CRLs and their modularity
Type of CRL | Cullin scaffold | RING-finger protein | Adaptor protein | Substrate recognition protein |
|---|---|---|---|---|
CRL1 | CUL1 | ROC1 (Rbx1) | Skp1 | F-box |
CRL2 | CUL2 | ROC1 (Rbx1) | Elongin B/Elongin C | VHL-box |
CRL3 | CUL3 | ROC1 (Rbx1) | BTB | |
CRL4A | CUL4A | ROC1 (Rbx1) | DDB1 | DCAF |
CRL4B | CUL4B | ROC1 (Rbx1) | DDB1 | DCAF |
CRL5 | CUL5 | ROC2 (Rbx2) | Elongin B/Elongin C | SOCS-box |
CRL7 | CUL7 | ROC1 (Rbx1) | Skp1 | Fbw8 |
CRL9 | CUL9 (PARC) | ? | ? | ? |