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Fig. 3 | Molecular Brain

Fig. 3

From: Systemic injection of nicotinic acetylcholine receptor antagonist mecamylamine affects licking, eyelid size, and locomotor and autonomic activities but not temporal prediction in male mice

Fig. 3

Effects of mecamylamine on the performance in the temporal conditioning task. A Examples of the effect of mecamylamine on licking responses in a mouse (N = 1, 250 trials each). Each color indicates drug conditions. Upper panel shows the raster plots of the licking responses. Bottom plot shows the histogram of the licking responses. The vertical axis indicates the time from the reward delivery. The horizontal axis indicates the frequency of licking. B Summary of the effect of mecamylamine on both anticipatory and consummatory licking (N = 6, 250 trials each). “Anticipatory” indicates anticipatory licking. “Con” indicates consummatory licking. We defined anticipatory licking as the period from 5 s before the time of sucrose solution delivery to the time of sucrose solution delivery, and consummatory licking as the period from the time of sucrose solution delivery to 1 s after the time of sucrose solution delivery. C Examples of the effect of mecamylamine on the eyelid size in a mouse (N = 1, 250 trials each). Top: Individual plot of the eyelid size. Bottom: heatmap of the eyelid size. D Summary of the effect of mecamylamine on the eyelid size (N = 6, 250 trials; **p < 0.01, *p < 0.05). E Examples of eye-opening in a mouse. F Examples of eye-closure in a mouse. “MEC” indicates mecamylamine. Error bars indicate standard error of the mean

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Molecular Brain

ISSN: 1756-6606