Fig. 7
From: Silencing of hypothalamic FGF11 prevents diet-induced obesity
Schematic diagram of Fgf11 knockdown in prevention of obesity. Fgf11 knockdown increases tyrosine phosphorylation of GSK3α and GSK3β, thereafter reducing CREB phosphorylation to decrease NPY expression. This results in a reduction of NPY projection into the TH neurons in the PVN, leading to increased TH expression. Consequently, TH induction elevates BAT thermogenesis, reducing body weight