Fig. 3
From: MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning
Synchrony of neuronal activities in area M1 changes differently between Mecp2-null mice and WT littermates when motor deficit progresses. A Heat map plot of Ca2 + activities from each week of a representative WT and Mecp2-null mouse showing synchrony changes during rest and locomotion over development. The bar represents 120 sec-long. B Averaged Pearson correlation coefficient across imaged ages during rest (left) and during locomotion (right). Black, WT (n = 9); Blue, Mecp2-null (n = 8). *P < 0.01, genotype by time interaction, mixed effects models ANOVA. C Event synchrony binned by intersomatic distance for early imaging sessions (weeks 6–7, 1st panel), late imaging sessions (weeks 9–10, 2nd panel), and early vs. late sessions for WT (3rd panel) and Mecp2-null (4th panel)