Fig. 4

Neuronal synchrony in neurons differently tuned to locomotion speed. A Example correlation matrices sorted by cell type for a WT mouse and Mecp2-null mouse during rest (top) and during locomotion (bottom) across ages. The top 8 rows of each matrix are from running-selective cells, and the bottom 8 rows are from rest-selective cells. The top-left quadrant of each matrix shows Pearson correlations between running-selective cells, the bottom-right quadrant shows correlations for rest-selective, and bottom-left and top-right quadrants show correlations between cell types. B–E Synchrony within running-selective cells (B), rest-selective cells (C), between running-selective and rest-selective cells (D) and within non-selective cells (E) across ages, during rest (left) and locomotion (right). Black line, WT, Blue line, Mecp2-null. Error bars are the 95% confidence intervals calculated by subsampling pairs from each animal per imaging time point, the number of pairs set to guarantee the same numbers of pairs are analyzed from at least 5 animals per timepoint, and calculating the mean values 1000 times. *P < 0.05, genotype by time interaction, mixed effects models ANOVA. F Same data plotted in D–E, but with 3 different cell types plotted on the same graph, to show the differences between cell types. Left panels rest, right panels locomotion