Table 3 TREM-1 expression in CNS diseases
Disease | TREM-1 Isoform | Sample | Results | Refs. |
|---|---|---|---|---|
Ischemic Stroke | TREM-1 | Serum | TREM-1 levels were elevated and correlated with stroke severity | [83] |
Post-stroke depression (PSD) | sTREM-1 | Plasma | Reduced sTREM-1 levels in patients with PSD were negatively associated with the severity of depressive symptoms | [89] |
Subarachnoid hemorrhage | sTREM-1 | CSF | Early elevation of sTREM-1 was positively correlated with white blood cells, CRP, and the severity of the disease | [92] |
sTREM-1 | Plasma | sTREM-1 levels were elevated and positively correlated with Hunt-Hess classification and CRP levels | [95] | |
sTREM-1 | CSF | sTREM-1 levels were positively correlated with the Hunt-Hess classification | ||
Intracerebral hemorrhage | sTREM-1 | Serum | Elevated sTREM-1 levels may correlate with the severity of disease | [104] |
Alzheimer’s disease | TREM-1 | Blood | TREM-1 mRNA levels were elevated | [111] |
sTREM-1 | Plasma | Elevated sTREM-1 levels were positively correlated with AD progression and total tau protein levels | [112] | |
Gliomas | TREM-1 | Blood | Patients with TREM-1/TREM-2 ratios greater than 125 had shorter survival times than those with ratios less than 125 | [122] |
sTREM-1 | Serum | sTREM-1 levels were lower than that of normal subjects | [122] | |
Bacterial meningitis | sTREM-1 | CSF | sTREM-1 levels were elevated | [123] |
sTREM-1 | CSF | sTREM-1 levels were elevated and correlated with mortality | [124] | |
sTREM-1 | CSF | sTREM-1 levels were higher in surviving patients than in deceased patients | [125] | |
External ventricular drain-related ventriculitis | sTREM-1 | CSF | sTREM-1 concentrations were elevated | [126] |