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Table 1 Steady-state activation properties of TN-associated human Cav3.2 variants expressed in tsA-201 cells

From: Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia

 

Activation

CaV3.2

Gmax (nS/pF)

p

V0.5 (mV)

p

k (mV)

p

(n)

WT

0.84 ± 0.07

 

− 38.17 ± 0.80

 

6.38 ± 0.35

 

38

P30L

0.77 ± 0.11

 > 0.9999

− 44.18 ± 1.24

0.1251

4.70 ± 0.51

0.2024

15

S187L

1.01 ± 0.15

 > 0.9999

− 51.63 ± 2.56

 < 0.0001

3.47 ± 0.50

0.0006

17

I799V

0.65 ± 0.10

0.6889

− 41.78 ± 1.58

0.5519

5.62 ± 0.69

 > 0.9999

19

A802V

0.85 ± 0.09

 > 0.9999

− 48.82 ± 1.14

 < 0.0001

3.56 ± 0.45

0.0015

14

E819K

0.66 ± 0.12

 > 0.9999

− 48.19 ± 2.97

0.0208

4.31 ± 0.53

0.0491

14

Q1049H

0.70 ± 0.11

 > 0.9999

− 41.88 ± 2.42

 > 0.9999

4.99 ± 0.67

0.7660

14

P1120L

0.91 ± 0.13

 > 0.9999

− 49.55 ± 3.17

0.0106

4.23 ± 0.56

0.1175

10

P1605H

0.76 ± 0.06

 > 0.9999

− 34.53 ± 1.60

 > 0.9999

8.17 ± 0.34

0.2336

15

R1674H

0.37 ± 0.07

0.0185

− 38.23 ± 2.30

 > 0.9999

6.49 ± 0.99

 > 0.9999

8

R1736C

0.60 ± 0.05

0.8669

− 32.42 ± 1.38

0.4164

7.39 ± 0.29

 > 0.9999

15

D1779Y

0.72 ± 0.11

 > 0.9999

− 33.86 ± 1.12

 > 0.9999

8.08 ± 0.27

0.2457

15

P2280H

1.12 ± 0.16

 > 0.9999

− 53.12 ± 2.31

 < 0.0001

3.87 ± 0.37

0.0159

11

E2291K

0.81 ± 0.15

 > 0.9999

− 46.13 ± 2.01

0.0268

4.91 ± 0.69

0.1754

17