Activation | |||||||
---|---|---|---|---|---|---|---|
CaV3.2 | Gmax (nS/pF) | p | V0.5 (mV) | p | k (mV) | p | (n) |
WT | 0.84 ± 0.07 | − 38.17 ± 0.80 | 6.38 ± 0.35 | 38 | |||
P30L | 0.77 ± 0.11 | > 0.9999 | − 44.18 ± 1.24 | 0.1251 | 4.70 ± 0.51 | 0.2024 | 15 |
S187L | 1.01 ± 0.15 | > 0.9999 | − 51.63 ± 2.56 | < 0.0001 | 3.47 ± 0.50 | 0.0006 | 17 |
I799V | 0.65 ± 0.10 | 0.6889 | − 41.78 ± 1.58 | 0.5519 | 5.62 ± 0.69 | > 0.9999 | 19 |
A802V | 0.85 ± 0.09 | > 0.9999 | − 48.82 ± 1.14 | < 0.0001 | 3.56 ± 0.45 | 0.0015 | 14 |
E819K | 0.66 ± 0.12 | > 0.9999 | − 48.19 ± 2.97 | 0.0208 | 4.31 ± 0.53 | 0.0491 | 14 |
Q1049H | 0.70 ± 0.11 | > 0.9999 | − 41.88 ± 2.42 | > 0.9999 | 4.99 ± 0.67 | 0.7660 | 14 |
P1120L | 0.91 ± 0.13 | > 0.9999 | − 49.55 ± 3.17 | 0.0106 | 4.23 ± 0.56 | 0.1175 | 10 |
P1605H | 0.76 ± 0.06 | > 0.9999 | − 34.53 ± 1.60 | > 0.9999 | 8.17 ± 0.34 | 0.2336 | 15 |
R1674H | 0.37 ± 0.07 | 0.0185 | − 38.23 ± 2.30 | > 0.9999 | 6.49 ± 0.99 | > 0.9999 | 8 |
R1736C | 0.60 ± 0.05 | 0.8669 | − 32.42 ± 1.38 | 0.4164 | 7.39 ± 0.29 | > 0.9999 | 15 |
D1779Y | 0.72 ± 0.11 | > 0.9999 | − 33.86 ± 1.12 | > 0.9999 | 8.08 ± 0.27 | 0.2457 | 15 |
P2280H | 1.12 ± 0.16 | > 0.9999 | − 53.12 ± 2.31 | < 0.0001 | 3.87 ± 0.37 | 0.0159 | 11 |
E2291K | 0.81 ± 0.15 | > 0.9999 | − 46.13 ± 2.01 | 0.0268 | 4.91 ± 0.69 | 0.1754 | 17 |