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Table 2 Steady-state inactivation and recovery from inactivation properties of TN-associated human Cav3.2 variants expressed in tsA-201 cells

From: Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia

 

Inactivation

Recovery from inactivation

CaV3.2

V0.5 (mV)

p

k (mV)

p

(n)

τ (ms)

p

(n)

WT

− 61.61 ± 1.75

 

− 4.48 ± 0.22

 

19

644 ± 49

 

15

P30L

− 65.95 ± 2.67

 > 0.9999

− 4.75 ± 0.44

 > 0.9999

7

705 ± 200

 > 0.9999

5

S187L

− 70.21 ± 3.99

0.8716

− 4.10 ± 0.34

 > 0.9999

7

400 ± 39

0.6749

6

I799V

− 64.22 ± 1.71

 > 0.9999

− 4.27 ± 0.51

 > 0.9999

10

382 ± 76

0.1542

8

A802V

− 70.79 ± 3.80

0.3699

− 4.16 ± 0.39

 > 0.9999

6

241 ± 28

0.0001

10

E819K

− 65.31 ± 2.86

 > 0.9999

− 5.18 ± 0.55

 > 0.9999

9

335 ± 38

0.1564

5

Q1049H

− 65.68 ± 1.74

 > 0.9999

− 4.44 ± 0.28

 > 0.9999

7

185 ± 24

0.0005

5

P1120L

− 64.38 ± 3.53

 > 0.9999

− 3.64 ± 0.57

 > 0.9999

7

489 ± 197

0.4634

6

P1605H

− 61.32 ± 0.51

 > 0.9999

− 5.10 ± 0.19

 > 0.9999

12

470 ± 46

 > 0.9999

10

R1674H

− 63.29 ± 2.49

 > 0.9999

− 6.05 ± 1.04

 > 0.9999

7

397 ± 103

0.3918

6

R1736C

− 62.48 ± 0.73

 > 0.9999

− 5.50 ± 0.11

0.0191

12

665 ± 68

 > 0.9999

7

D1779Y

− 64.23 ± 1.07

 > 0.9999

− 5.03 ± 0.11

 > 0.9999

12

662 ± 58

 > 0.9999

8

P2280H

− 74.22 ± 1.89

0.0015

− 4.56 ± 0.37

 > 0.9999

10

334 ± 42

0.0724

7

E2291K

− 65.27 ± 1.83

 > 0.9999

− 4.23 ± 0.19

 > 0.9999

11

429 ± 80

0.3967

8