Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia

Table 3 Summary of gating effects of TN-associated Ca_v3.2 variants in relation to the clinical phenotype of patients

Idiopathic TN**	Ca_v3.2 variant	Classical TN**	Ca_v3.2 variant
iTN-1	E286K*	cTN-1	E2291K
iTN-1	G563R*
iTN-1	R1674H	cTN-2	*P30L*
iTN-1	*D1779Y*	cTN-2	H526Y*
		cTN-2	*I799V*
iTN-2	P566T*	cTN-2	*P1605H*
iTN-2	E819K	cTN-2	*R1736C*
iTN-2	Q1049H	cTN-2	*P30L*
iTN-2	P1120L
iTN-2	P2280H

Italic: GoF
Bold: LoF
Bolditalic: Neutral
iTN idiopathic trigeminal neuralgia, cTN classical trigeminal neuralgia; (− 1), purely paroxysmal; (− 2) with concomitant continuous pain. *According to [17]. **According to [25]. Two GoF variants (S187L and A802V) are not included in this table since their clinical phenotype was not fully defined (atypical facial pain and TN without further information, respectively)

ISSN: 1756-6606