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Fig. 3 | Molecular Brain

Fig. 3

From: Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice

Fig. 3

Transcriptomic evidence for the immature dentate gyrus phenotype in Cn mutant mice. a Volcano plot showing the differentially expressed genes (DEGs) identified by microarray analysis. b Pathway enrichment analysis of the DEGs using BaseSpace. Full list is available in the Additional file 2: Table S4. c The gene expression pattern in the DG of adult Cn mutant mice (mutants compared to controls) was compared with typically developing infant mice (2-week-old vs. 4-week-old wild-type mice). d Venn diagram illustrating the overlap in transcriptome‐wide gene expression changes in the DG of adult Cn mutant mice and infant mice. e P‐values of overlap between the adult Cn mutant mice and infant mice in the DG datasets. Bar graphs illustrate the P‐values of overlap of genes upregulated (red arrows) or downregulated (blue arrows) by each condition, between the two conditions. f Overlap P-values and the number of common genes/transcripts responsive to both conditions for each pair of interest. iDG mouse, mouse with immature dentate gyrus (iDG) phenotypes

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Molecular Brain

ISSN: 1756-6606