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Fig. 1 | Molecular Brain

Fig. 1

From: Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders

Fig. 1

Key aspects of NOP receptor signalling. A. NOP receptors at synaptic terminals. Activation of NOP by N/OFQ triggers several G protein dependent signalling pathways. B. Activation of NOP receptors triggers Gβγ mediated voltage-dependent inhibition of Cav2.2 channels, as well as Gα/tyrosine kinase dependent voltage independent modulation. Due to the formation of signalling complexes, prolonged agonist application triggers the co-internalization of NOP receptor Cav2.2 channel complexes

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Molecular Brain

ISSN: 1756-6606