Fig. 1
From: Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
Effects of CHRM subtype-selective agonists and antagonists on CHRM density and locomotor activity in DD mice. (a–c) Binding assays with [3H]pirenzepine, [3H]AFDX-384, and [3H]4-DAMP were conducted. WT mice: n = 5, DD mice: n = 5. **p < 0.01 (Student’s t-test). The data are expressed as the mean + SEM with data point overlap. (d-h) Change in locomotor activity in WT mice (n = 11–12) and DD mice (n = 9–12) following xanomeline, arecaidine propargyl ester tosylate, VU0255035, AQRA-741, and saline treatment. *p < 0.05, **p < 0.01 (two-way repeated-measures ANOVA). The data are expressed as the mean ± SEM