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Fig. 6 | Molecular Brain

Fig. 6

From: Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping

Fig. 6

The expression of c-fos in I and II laminae of TNC after CSD. The dotted frame represents the I and II laminae of TNC. A In KCl model, CSD resulted in significant c-fos expression in ipsilateral I and II laminae of TNC compared with NaCl group (p = 0.0168, t-test), optogenetic CSD group (hChR2 group) (p = 0.001, t-test) and EYFP group (p = 0.0012, t-test). B The I and II laminae of TNC in VISoR images, the ipsilateral c-fos expression was not significant between CSD and control group. C In CSD group, the c-fos in ipsilateral and contralateral was not significant. D Images of c-fos expression in I and II laminae of TNC in KCl group. E The contralateral of TNC in KCl group. F The ipsilateral of TNC in KCl group. G Images of c-fos expression in I and II laminae of TNC in NaCl group. H The contralateral of TNC in NaCl group. I The ipsilateral of TNC in NaCl group. J Images of c-fos expression in I and II laminae of TNC in optogenetic CSD group. K The contralateral of TNC in optogenetic CSD group. L The ipsilateral of TNC in optogenetic CSD group. M Images of c-fos expression in I and II laminae of TNC in control group. (N) The contralateral of TNC in control group. O The ipsilateral of TNC in control group. P VISoR images of c-fos expression in I and II laminae of TNC in optogenetic CSD group. Q VISoR images of c-fos expression in I and II laminae of TNC in control group

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