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Fig. 3 | Molecular Brain

Fig. 3

From: Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease

Fig. 3

Amyloid beta deposition in the brain tissues of 5xFAD TG mice with or without OA. A Representative immunofluorescence images showing amyloid plaques in the hippocampus and cortex of TG mouse brains 4 months after surgical DMM. Graphs showing B, D amyloid beta plaque size and C, E amyloid beta plaque count per field in the hippocampus and cortex of TG sham and TG OA mice (at least 16 brain images/group). Values are expressed as mean ± SEM (n = 4/group). Student’s t-test was used for statistical analyses. **P < 0.01, *P < 0.05 were considered significant for the comparison between TG sham and TG OA; ns not significant

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