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Fig. 4 | Molecular Brain

Fig. 4

From: Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease

Fig. 4

Neuronal loss in the brain tissues of TG mice with or without OA. A Representative immunoblot of MBP protein expression in brain tissues of TG mice with or without OA. B MBP protein fold change compared with the WT sham control. Band intensities were normalized to GAPDH (n = 4/group). One-way ANOVA with Tuckey test. C Representative images showing Neu-N immunostaining in the cortex region of mice brains 4 months after surgical DMM. D Neu-N-positive cell count per field. E Representative images showing neurons in the hippocampal CA1 region at 4 months after surgical DMM. F DAPI count per field in TG sham and TG OA brain tissues (9 images per brain, n = 4). G Graphical summary. Values are expressed as mean ± SEM. Student’s t-test was used for statistical analyses. ***P < 0.001, *P < 0.05 for the comparison between TG sham and TG OA; ns not significant

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