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Fig. 5 | Molecular Brain

Fig. 5

From: 14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson’s disease-like motor incoordination in mice

Fig. 5

Increased expression of the glial fibrillary acidic protein in the substantia nigra of the 14-3-3γ heterozygous mice. a, b Representative western blotting image (a) and quantitative graph (b) of the glial fibrillary acidic protein (GFAP) in brain homogenates of the 14-3-3γ HET mice and CTL mice (n = 4 per group). c Immunochemistry results for GFAP expression enhanced in the substantia nigra (SN) region and not significantly enhanced in the striatum (ST) region in the 14-3-3γ HET mice brain and the CTL mice brain (scale bar, 0.2 μM). d, e Quantitative graphs of GFAP immunostaining intensity in the ST (d) and SN (e) regions of the 14-3-3γ HET mice brain and the CTL mice brain (n = 4 per group). Results are presented as means ± SEM; *P < 0.05, **P < 0.01 and ***P < 0.001. (CTL littermate wild-type control, HET heterozygous, GFAP glial fibrillary acidic protein, ST striatum, SN substantia nigra, DAPI 4,6-diamidino-2-phenylindole, SEM standard error of mean, ns non-significant)

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