Fig. 6

Defect in the motor coordination of 14-3-3γ heterozygous mice without a decrease in the basal motor activity. a Representative image showing the standard scoring system for the hindlimb clasping test (HCT). b The 14-3-3γ HET mice show a significant increase in the clasping scores (n = 8 per group). c, d Crossover latency in the 14-3-3γ HET mice was significantly increased for both wide and narrow beams in the balance beam test (BBT) (n = 24 CTL and n = 21 HET). e Images showing the failed trials of the 14-3-3γ HET mice on the narrow beam. f Fall latency was recorded for the 14-3-3γ HET and CTL mice on a rotating rod moving in an accelerated manner in four rota-rod tests (RRT) experiments (n = 8 CTL and n = 7 HET). g The mean of the data from the four trials presented here showed no significant difference in basal motor activity between groups. Results are presented as means ± SEM; *P < 0.05 and **P < 0.01. (CTL littermate wild-type control, HET heterozygous, SEM standard error of the mean)