Fig. 2
From: Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex
Pain-evoked event-related potentials (ERPs) and Z-score analysis of the pain decoder showed temporal sequence in cortical response to a mechanical stimulus. A Illustration of raw LFP trace of ACC and S1. ERPs are marked by black triangles. Onset of a noxious mechanical stimulus (pin prick, PP) is marked by the black vertical line. The red curve indicates LFP signals in the ACC and the blue curve indicates LFP signals in the S1. The arrow marks the time of the ERP peak latency. B Comparison of the ERP peak latency between the ACC and S1 (n = 96 trials from 5 rats). On average, the ERP peak latency in the ACC was longer than that of the S1 (n = 96; ****p < 0.0001, paired t test). C Illustration of Z-score curve of the SSM-based pain decoder in the ACC and S1 (see Methods for details). Z-score peak is marked by the black triangle. The onset of PP is marked by the black vertical line. The red curve indicates the Z-score curve in the ACC and the blue curve indicates Z-score curve in the S1. The arrow marks the time of the Z-score peak latency. D Comparison of Z-score peak latency between the ACC and S1 (n = 96 trials from 5 rats). The latency in the ACC was longer than the latency in the S1 (n = 96; **p = 0.0014, paired t test)