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Fig. 4 | Molecular Brain

Fig. 4

From: Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice

Fig. 4

Synaptic tagging occurred in female mice. Summarized plot of the fEPSPs slope demonstrates that both strong TBS at site S1 and tagging TBS at site S2. Either adult female mice (n = 5 slices/5 mice) or middle-aged female mice (n = 4 slices/4 mice) could induce L-LTP on site S1 (a). Tagging-like response could be induced in adult female mice (n = 5 slices/5 mice) but not in middle-aged female mice on site S2 (n = 3 slices/3 mice) (b). Polygonal diagrams of channel data in each group (4 groups, n = 5) pooled from slices with the tagging-like response. c, e, g, i The channels were activated in the baseline (blue, pre) and at 4.5 h after strong TBS of the site S1 (red, post) in the slice. Black dots represent the 64 channels in the MED64 system. Vertical dashed lines indicate the layers in the ACC slice. d, f, h, j Polygonal diagrams of the channels of pool data that were activated in the baseline state (blue, pre) and at 4 h after tagging TBS (red, post) at site S2. Delivery of strong TBS resulted in an enlargement of the activation area in all groups, while tagging TBS recruit less or no new synaptic responses in the ACC in adult and aged groups

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