Fig. 4
From: Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
Working memory is impaired after sustained inhibition of protein synthesis. A Immunofluorescence analysis of p-S6 (Ser240/244) in 4EHP-cKOexc vs. WT mouse hippocampus. B Quantification of p-S6 integrated density was performed on CA1 pyramidal neurons using image J. Scale bar represents 60 µm. C Immunofluorescence analysis of p-S6 (Ser240/244) in Rptorflx/flx:Camk2a-Cre mouse hippocampus compared to Rptor+/+:Camk2a-Cre. D Discrimination index for T-maze working memory in Rptorflx/flx:Camk2a-Cre (n = 14) compared to Rptor+/+:Camk2a-Cre (n = 10). E Total exploration time of both maze arms. Data are presented as mean ± s.e.m.; **p < 0.01; ns, not significant. P value calculated using unpaired t-test. ###p < 0.001, calculated using one sample t-test. Sample size is located within the bar graph for each group