Fig. 3
From: Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Circadian regulation of the BBB. The circadian rhythm regulates various aspects of BBB integrity such as tight junction efficacy, transporter activity, and NVU function. Under healthy conditions these functions work in harmony to maintain homeostasis and BBB integrity. However, when the circadian rhythm is disturbed signaling pathways become disrupted and loss of function or dysregulation ensues. Examples of such shown in the figure include (1) astrocyte to endothelial cell interactions disruption, (2) loss of pericyte coverage, (3) microglia communication disruption, (4) transporter protein function and tight junction efficacy loss. Created with BioRender.com