Fig. 4
From: Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Circadian interactions in regulation of proteasomal activity. Proteasomal activity follows a circadian rhythm. Circadian disruption can result in rhythm of activity disruption, overproduction of proteins, and improper ubiquitination of inappropriate structures. Many neurodegenerative diseases involve an accumulation of these protein products that form meta-stable plaques, the formation of such leads to a loss of neuroprotection