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Fig. 3 | Molecular Brain

Fig. 3

From: The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain

Fig. 3

Immunohistochemical distribution of NLGN4 in the human hippocampus. A A representative image of the adult hippocampus (case ID: A6). Intense NLGN4 signals were observed in the pyramidal cell layer (black arrowheads), while no signals were observed in the granule cell layer (white arrowheads). B A magnified view of the boxed area in A. Clear NLGN4 signals were observed in pyramidal neurons in the hippocampus. C A high-magnification view of the pyramidal cell layer in case A6 examined with anti-NL4-m1 (1:1000 dilution). Clear signals with relatively high background were observed. D A high-magnification view of the pyramidal cell layer in another adult brain (case ID: A4). Intense signals were observed in most pyramidal neurons. E A representative image of the neonatal hippocampus (case ID: N5). Intense NLGN4 signals were observed in the granule cell layer (white arrowheads) as well as in the pyramidal cell layer (black arrowheads). F A high-magnification view of the pyramidal cell layer in another neonatal brain (case ID: N2). Intense NLGN4 signals were observed in most pyramidal neurons. G A high-magnification view of the pyramidal cell layer in the infantile brain (case ID: I1). H A high-magnification view of the pyramidal cell layer in case I1 examined with anti-NL4-m1 (1:1000 dilution). Clear NLGN4 signals were observed in pyramidal neurons, as in G. Scale bars = 1 mm (A), 100 μm (B–D, F–H), 500 μm (E)

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