Fig. 7
From: The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain
The majority of oxytocin-producing neurons and arginine vasopressin-producing neurons in the human hypothalamus express NLGN4. A–D Representative paired images of NLGN4 distribution (A, B) and arginine vasopressin (AVP) distribution (C, D) in the adult PVN (case ID: A2). Mirror sections were prepared and immunostained with either anti-NL4-p1 antibodies or anti-AVP antibodies. A, C Low-magnification views. B, D Magnified views of the boxed areas in A and C, respectively. Asterisks indicate cells regarded as identical in B and D. E–H Representative paired images of NLGN4 distribution (E, F) and oxytocin (OXT) distribution (G, H) in the neonatal SON (case ID: Ni). E, G Low-magnification views. F, H Magnified views of the boxed areas in E and G, respectively. Asterisks indicate cells regarded as identical in F and H. Scale bars = 500 µm (A, C, E, G), 100 µm (B, D, F, H). I Ratios of NLGN4-positive neurons among AVP-positive neurons (NLGN4 + /AVP +) and NLGN4-positive neurons among OXT-positive neurons (NLGN4 + /OXT +) in the adult and neonatal PVN and SON. The values are shown as percentages. Details of cases Ni, Nii, and Ai are described in the text