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Fig. 1 | Molecular Brain

Fig. 1

From: Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice

Fig. 1

Persistent pain induced by sciatic nerve ligation or paw electrocautery operation promotes tumor growth. A Experimental timeline. B Changes in the pain threshold induced by sciatic nerve ligation under the tumor-bearing state, measured by a plantar test (n = 7–10, Two-way repeated measures ANOVA with the post-hoc Bonferroni test, ***p < 0.001 vs. Sham + LLC/Ipsi). Contra: Contralateral paw, Ipsi: Ipsilateral paw. C Quantitative analysis of tumor volume in the Sham + LLC and Ligation + LLC groups (n = 13–15, Two-way repeated measures ANOVA with the post-hoc Bonferroni test, **p < 0.01 vs. Sham + LLC). D Experimental timeline. E Changes in the pain threshold induced by paw electrocautery operation in the tumor-bearing state, measured by the von Frey test (n = 16, Two-way repeated measures ANOVA with the post-hoc Bonferroni test, ***p < 0.001 vs. Sham + LLC/Ipsi). F Quantitative analysis of tumor volume in the Sham + LLC and Electrocautery + LLC groups (n = 16, Two-way repeated measures ANOVA with the post-hoc Bonferroni test, ***p < 0.001 vs. Sham + LLC)

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