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Fig. 2 | Molecular Brain

Fig. 2

From: PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain

Fig. 2

Gene targeting of the mouse Pdzd8 locus. a Schematic representation of the domain structure of PDZD8, the corresponding ORF, and the genomic structure of the Pdzd8 locus. Exons (Ex) and introns of the gene are shown as boxes and lines, respectively. b Schematic representation of the domain structure for the ORF products of wild-type (WT), Ex3d (from EUCOMM) [25], and Ex1d alleles of Pdzd8. The genotype, genotype abbreviation, as well as corresponding numbers of nucleotides and amino acids are also shown. c Schematic representation of the genomic structure around exon 1 of Pdzd8 showing the positions targeted by the two sgRNAs for generation of the Ex1d allele. The sequences of the WT and Ex1d alleles are also shown, with exon 1 and the adjacent upstream and intron sequences being highlighted in black and gray, respectively

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