Skip to main content
Fig. 7 | Molecular Brain

Fig. 7

From: PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain

Fig. 7

Social behavior of PDZD8-deficient mice. a–e Duration of contacts (a), number of contacts (b), duration of active contacts (c), mean duration per contact (d), and distance traveled (e) in the social interaction test of social behavior in a novel environment. Data are means + s.e.m. (n = 9 for WT and PDZD8-KO mice). f–i, Mean number of particles calculated for each hour over 7 days (f) and averaged over the last 3 days (g) as well as mean activity level (A.U., arbitrary units) for each hour over 7 days (h) and averaged over the last 3 days (i) in the home-cage social interaction test of social behavior in a familiar environment. Time is indicated in Zeitgeber time (ZT). Data are means ± s.e.m. (n = 8 for WT and PDZD8-KO mice). j–p, The time spent in the chamber containing an empty cage, in the center chamber, and in the chamber with a cage containing an unfamiliar mouse (stranger 1) (j); the time spent around each cage (l); the number of approaches to each cage (n); and the distance traveled (p) were determined in the three-chamber sociability test (1st trial). The time spent in the chamber containing caged stranger 1, the center chamber, and the chamber with a cage now containing a novel unfamiliar mouse (stranger 2) (k); the time spent around each cage (m); the number of approaches to each cage (o); and the distance traveled (p) were also determined in the three-chamber social novelty preference test (2nd trial). Data are means + s.e.m. (WT mice, n = 18; PDZD8-KO mice, n = 19). P values for differences between genotypes were determined with Student’s t test (a, b, d, e, j, l–p), the Mann–Whitney U test (c, j–l, o), two-way repeated-measures ANOVA (f–i), or Welch’s t test (k, m).*P < 0.05, **P < 0.01, ***P < 0.001; n.s., not significant. The results of all statistical analysis are provided in Additional file 2: Table S2

Back to article page