Fig. 9

Learning and memory of PDZD8-KO mice. a–d Latency to reach the target hole (a) as well as the number of errors (b), distance traveled (c), and number of omission errors (d) before reaching the target hole during training sessions in the Barnes maze test of spatial-learning memory and remote memory. e, f Time spent around each hole in probe trials conducted 1 day (e) and 30 days (f) after the last training session of the Barnes maze test. All data for a–f are means ± s.e.m. (WT mice, n = 17; PDZD8-KO mice, n = 16). g Percent correct responses in the T-maze test of working memory. Data are means + s.e.m. (WT mice, n = 18; PDZD8-KO mice, n = 19). P values for differences between genotypes were determined by two-way repeated-measures ANOVA (a–d, g) or the Mann–Whitney U test (e, f). **P < 0.01; n.s., not significant. The results of all statistical analysis are provided in Additional file 2: Table S2