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Fig. 5 | Molecular Brain

Fig. 5

From: G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses

Fig. 5

GPER1 is involved in activity-dependent LTP at TA-CA1 synapses. A–D Plots of pooled data illustrating effects on synaptic transmission at juvenile TA-CA1 synapses. A Delivery of HFS (shown by arrow) resulted in the induction of LTP, however subsequent addition of G1 failed to alter synaptic transmission. B Application of G1 induced cLTP, but subsequent delivery of HFS failed to increase synaptic transmission further. Activity-dependent LTP and GPER1-induced LTP share analogous expression mechanisms. C In control slices, HFS readily induced LTP. D In interleaved slices exposed to the GPER1 antagonist, G15 (200 nM), delivery of HFS failed to induce LTP. GPER1 activation is involved in activity-dependent LTP

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Molecular Brain

ISSN: 1756-6606