Fig. 1

Schematic diagram of an electrostimulable microfluidic device system. A Schematic diagram of the microfluidic device system (left). Magnified view of the microchannel area with electrode holes (right). Yellow circles indicate electrode holes for simple insertion of electrodes. Microchannel (blue) and synapse canal (green) are localized between cortical and striatal areas. B 3D schematic diagram of the microfluidic device. Electrodes for electrical stimulation are connected via electrode holes (yellow). The reservoir in the synapse canal is directly connected to the synaptic canal to allow for perfusion. C Schematic depiction of the microfluidic device with CStr circuits. Cortical axons pass through axonal microchannels, and striatal dendrites pass through dendrite microchannels. D The microfluidic device with attached cover glass after plasma coating