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Fig. 2 | Molecular Brain

Fig. 2

From: Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective

Fig. 2

Blockade of mPGES-1 blunts post-SE neuroinflammation. A The mRNA expression of cytokines (IL-1β, IL-6, and TNF-α), chemokines (CCL2, CCL3, and CCL4), and gliosis biomarkers (Iba1 and GFAP) in the hippocampus was measured by qPCR 4 d after pilocarpine-induced SE in mice (N = 6, **P = 0.0021, ratio t test). B Immunostaining for Iba1 and GFAP was performed 4 d after SE to visualize reactive microglia and astrocytes in the hippocampus, respectively. The overall density of fluorescence (red) was used to indicate the levels of gliosis. Note that nuclear counterstain was performed with DAPI (blue fluorescence). Scale bar = 100 μm. C Quantification of the protein expression of Iba1 and GFAP in the hippocampi of SE mice that were treated by vehicle or PBCH (N = 6, P = 0.5842 for Iba1; P = 0.4135 for GFAP, unpaired t test). Data are presented as mean + SEM

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