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Fig. 2 | Molecular Brain

Fig. 2

From: Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

Fig. 2

Deficient locomotor functions in Ggps1 cKO mice. A Representative footprints of the mice and quantification of average footstride length. Red lines represent the paths of the fore feet, and black ones for the hind feet. Abnormal footprints were seen in Ggps1 cKO mice at P16 and there was significant difference between control and Ggps1 cKO mice at P16 (***P = 4.7 × 10–7, ***P = 6.9 × 10–8, respectively; n = 6 for WT, n = 7 for cKO). The scale bar is 1 cm. B The average latency to fall in a rotarod task. There was significant difference between control and Ggps1 cKO mice at P16 (***P = 4.1 × 10–6; n = 9 for WT, n = 7 for cKO). C The average latency to fall in a beam-walking task. There was significant difference between control and Ggps1 cKO mice at P16 (***P = 2.5 × 10–12; n = 10 mice per group). D Performance in an open-field task. There were significant differences on the total distance traveled and the time spent in the central area between control and Ggps1 cKO mice at P16 (***P = 9.0 × 10–5, **P = 0.002, respectively; n = 10 for WT, n = 8 for cKO)

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Molecular Brain

ISSN: 1756-6606