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Fig. 4 | Molecular Brain

Fig. 4

From: Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

Fig. 4

Loss of astrocytes in Ggps1 cKO mice. A, B Representative fluorescence IHC images for Blbp using brain sections at E17.5 (A) and P0 (B). The scale bars were indicated in the images. C The average number of Blbp + cells in the cerebellum. There was significant difference between control and Ggps1 cKO mice at P0 but not E17.5 (*P = 0.045, n = 5 mice per group at each age). D Representative fluorescence images for co-staining of Ggpps/Blbp on brain sections at P4 and P7. There were abundant Blbp + cells in the control cerebellum at each age. In contrast, the size of the cerebellum was very small and the population of Blbp + cells was dramatically reduced in Ggps1 cKO mice. E Enlarged images for the boxed areas in D. The fiber of Blbp + cells (red fluorescence) was abundantly co-stained with Ggpps (green fluorescence) in the control cerebellum (a), but it showed almost no green signals in the cKO cerebellum (b)

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Molecular Brain

ISSN: 1756-6606