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Fig. 7 | Molecular Brain

Fig. 7

From: The deficiency of Maged1 attenuates Parkinson's disease progression in mice

Fig. 7

Maged1 knockout in mice prevents dopaminergic neurodegeneration in elderly mice. A Typical immunostaining for TH (red), Iba1 (green), and DAPI (blue) in the midbrain of 15-month-old mice. Scale bar: 200 μm. B, C Quantification of TH-positive cells B or Iba1-positive cells C in A (% of WT). D Representative images of TH-positive fibers in striatum sections. Scale bar: 200 μm. E Quantitative of the optical density of TH-positive fibers in D using ImageJ software. F, G Western blot analysis of TH expression from the midbrain of 2-month-old and 15-month-old mice. H Iba1 immunostaining in the striatum of 15-month-old mice. Scale bar: 200 μm. For A–H, n = 4 mice per group. Data are shown as means ± SE. *P < 0.05, **P < 0.01, ***P < 0.001, #P < 0.05

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