Fig. 3

Comparison of properties between Nav1.8^ChR2-positive and Nav1.8^ChR2-negative Aβ-mechanoreceptors. A Sample traces show SA AP impulses evoked by indentations (5, 30, and 80 mN) in a Nav1.8^ChR2-positive Aβ-fiber SA-mechanoreceptor. B&C) Two sets of sample traces show SA (B) and RA (C) AP impulses evoked by indentations (5, 30, and 80 nN) in a Nav1.8^ChR2-negative Aβ-fiber SA-mechanoreceptors (B) and a Nav1.8^ChR2-negative Aβ-fiber RA-mechanoreceptors. D Percent of Nav1.8^ChR2-positive and Nav1.8^ChR2-negative Aβ-mechanoreceptors that display SA or RA impulses. Recording numbers are indicated in the bars. E Conduction velocity of Nav1.8^ChR2-positive Aβ-fiber SA-mechanoreceptors, Nav1.8^ChR2-negative Aβ-fiber SA-mechanoreceptors, and Nav1.8^ChR2-negative Aβ-fiber RA-mechanoreceptors. F Frequency of impulses evoked by different indentation forces in Nav1.8^ChR2-positive Aβ-fiber SA-mechanoreceptors, Nav1.8^ChR2-negative Aβ-fiber SA-mechanoreceptors, and Nav1.8^ChR2-negative Aβ-fiber RA-mechanoreceptors. G, H Indenter (G) and von Frey (H) mechanical force thresholds for evoking AP impulses in Nav1.8^ChR2-positive Aβ-fiber SA-mechanoreceptors (n = 23), Nav1.8^ChR2-negative Aβ-fiber SA-mechanoreceptors (n = 18), and Nav1.8^ChR2-negative Aβ-fiber RA-mechanoreceptors (n = 8). Data represent individual observations and/or mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001