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Fig. 1 | Molecular Brain

Fig. 1

From: Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases

Fig. 1

A multi-stage analysis methodology was employed in this study. Transcriptomic datasets of the developing human brain were collected from the Atlas of the Developing Human Brain. The GClTC were defined using the Gene Ontology database. STEM software was used to cluster genes with similar temporal expression patterns. Functional enrichment analyses of different clusters were performed to identify significantly-enriched pathways and GO terms. We selected the clusters related to the CNS and explored the cell type and brain region distribution of GClTC in those clusters. Combining those expression features with enriched diseases, we illustrate their intrinsic connections. GO Gene Ontology, KEGG Kyoto encyclopedia of genes and genomes, CNS Central nervous system, STEM short time-series expression miner

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Molecular Brain

ISSN: 1756-6606