Fig. 2

Anxiety-like and depression-related behaviors in 5-HTT-deficient mice. a–d Light/dark transition test: a distance traveled (cm) in the dark and light chambers, b number of transitions, c time spent in the light chamber (s), and d latency to enter the light chamber (s). e–h Open field test: e distance traveled (cm), f vertical activity, g center time (s), and h stereotypic counts for each 5-min block of testing. i–l Elevated plus maze test: i distance traveled (cm), j number of arm entries, k time spent in open arms (%), and l entries into open arms (%). m, n Porsolt forced swim test: m immobility time (%) and n distance traveled (cm) for each 1 min-block. o Immobility time (%) for each 1-min block in the tail suspension test. (p–r) Sucrose preference test: p water intake and q 1% sucrose intake, and r sucrose preference (%). Values are means ± SEM. Asterisks and daggers indicate statistically significant differences between groups (5-HTT−/− vs. 5-HTT+/+, *p < 0.05 and **p < 0.01; 5-HTT−/− vs. 5-HTT+/−, ^†p < 0.05 and ^††p < 0.01; 5-HTT+/− vs. 5-HTT+/+, ^§ p < 0.05 and ^§§p < 0.01)