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Fig. 4 | Molecular Brain

Fig. 4

From: FMRP binds Per1 mRNA and downregulates its protein expression in mice

Fig. 4

FMRP regulates PER1 protein expression in a temporal and tissue-dependent patterns in mice. A–C Western blot analysis of cortex lysates from WT and Fmr1 KO mice taken at the ZT0 and ZT12 of a day (A) and the quantification of Per1 (B) and FMRP (C) protein levels; Data are presented as means ± SEM; *P < 0.05; **P < 0.01; two-tailed Student’s t-test; n = 4 mice/genotype/time point. D–F Western blot analysis of hypothalamus lysates from WT and Fmr1 KO mice taken at the ZT0 and ZT12 of a day (A) and the quantification of Per1 (B) and FMRP (C) protein levels; Data are presented as means ± SEM; *P < 0.05; **P < 0.01; two-tailed Student’s t-test; n = 4 mice/genotype/time point. G–I Western blot analysis of liver lysates from WT and Fmr1 KO mice taken at the ZT0 and ZT12 of a day (A) and the quantification of Per1 (B) and FMRP (C) protein levels; Data are presented as means ± SEM; ns: P > 0.05; **P < 0.01; two-tailed Student’s t-test; n = 4 mice/genotype/time point

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