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Fig. 2 | Molecular Brain

Fig. 2

From: Tibial fracture surgery in elderly mice caused postoperative neurocognitive disorder via SOX2OT lncRNA in the hippocampus

Fig. 2

Upregulated lncRNA SOX2OT expression in the mouse model of tibial fracture. a GO term and KEGG pathway enrichment map of differential lncRNAs. b High expression of SOX2OT in lncRNA sequencing, verified using RT-PCR (P < 0.0001). c SOX2OT located on mouse chromosome 3 and Fxr1, Sox2, and Dnajc19 are upstream and downstream genes of SOX2OT in the Ensembl database. d Dnajc19, SOX2, and Fxr1 mRNA levels measured using RT-qPCR on days 1, 3, 7, and 14 after sham treatment or surgery. *P < 0.05, **P < 0.002 vs. sham group. e Western blot analysis showing SOX2 protein expression on days 1, 3, 7, and 14 day after sham treatment or surgery. *P < 0.05 vs. sham group; n = 6

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Molecular Brain

ISSN: 1756-6606