Fig. 2

Maturation of inhibitory synaptic excitation onto medium spiny neurons of the nucleus accumbens shell of C57BL/6J and BTBR mice. A. Representative traces of sIPSCs obtained from MSNs in the NAc shell of C57BL/6J (black) and BTBR mice (blue). B-C. Maturation of sIPSC frequency. Both C57BL/6J (B) and BTBR mice (C) showed an increase in sIPSC frequency across the first postnatal month. D-E. Maturation of sIPSC amplitude. C57BL/6J mice (D) showed a slightly earlier (P15) increase in sEPSC amplitude compared to BTBR mice (E; P21). F-G. Maturation of sIPSC tau. C57BL/6J mice (F) showed stable sIPSC tau from P4, whereas BTBR mice (G) showed an increase in tau between P4 and P30. H-I. Direct comparison of age-dependent changes in NAc MSN sIPSC frequency and amplitude between C57BL/6J (black circles) and BTBR (blue circles) strains. Compared to C57BL/6J mice, BTBR mice showed increased sIPSC frequency at P8 (H) and increased sIPSC amplitude at P6, P12 and P30 (I). *p < 0.05. C57BL/6J: P4 (9 cells/4 mice), P6 (8 cells/3 mice), P8 (14 cells/4 mice), P12 (10 cells/ 3 mice), P15 (11 cells/ 4 mice), P21 (8 cells/ 3 mice), P30 (8 cells/ 3 mice); BTBR: P4 (10 cells/3 mice), P6 (9 cells/3 mice), P8 (16 cells/5 mice), P12 (8 cells/ 3 mice), P15 (10 cells/ 3 mice), P21 (6 cells/ 3 mice), P30 (9 cells/ 3 mice)