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Fig. 4 | Molecular Brain

Fig. 4

From: Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder

Fig. 4

BTBR mice show decreased PFC-NAc glutamate release probability in early life. A. Schematic of experimental design. B. Top: P15, representative traces of light-evoked EPSC during paired-pulse stimulation (250 ms) from MSNs of C57BL/6J mice (black) and BTBR mice (blue). Bottom: summary plot showing increased PPR in MSNs from BTBR mice compared to MSNs from C57BL/6J mice. C. Top: P30, representative traces of light-evoked EPSC during paired-pulse stimulation (100 ms) from MSNs of C57BL/6J mice (black) and BTBR mice (blue). Bottom right: summary graph showing increased PPR in MSNs from BTBR mice compared to those from C57BL/6J mice. * p < 0.05. C57BL/6J: P15 (12 cells/ 6 mice), P30 (12 cells/ 4 mice); BTBR: P15 (9 cells/ 4 mice), P30 (7 cells/ 4 mice)

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Molecular Brain

ISSN: 1756-6606